Assessment of Vitamin D Status in Healthy Volunteers in Different Age Groups

Rajinder Prasad , KS Sodhi , Neeru Bhasker and Ashutosh Sharma

Abstract


Vitamin D is mainly produced during exposure to sunlight; UVB photos (290-315 nm) penetrate skin where they are absorbed by 7-dehydrocholesterol (7-DHC). The absorption of UVB radiation causes 7-DHC, a steroid, to open its B ring, forming precholecalciferol (pre-D3). Pre D3 undergoes rearrangement of its double bonds to form vitamin D3. Vitamin D is metabolized in the liver to 25- hydroxyvitamin D [25(OH)D], which is the major circulating and storage form that is delivered to tissue for further activation. Some 25(OH)D is converted in the kidney to a biologically active hormonal form, 1,25- dihydroxyvitamin D [1,25(OH) D].  A variety of factors, 2 including serum phosphorus and PTH, regulate the renal production of 1,25(OH) D. The 1,25(OH) D regulates 2 2 calcium metabolism through its interaction with the major target tissues, the bone and the intestine. Beside the small intestine and the osteoblast, vitamin D receptor (VDR) for 1,25(OH) D has been identified in brain, heart, skin, 2
pancreas, breast, colon, and immune cells. The 1,25(OH) D helps regulate cell growth and maturation, 2 stimulates insulin secretion, inhibits renin production, and modulates the functions of activated T and B lymphocytes
and macrophages. Thus, 1,25(OH) D has other important 2 functions in addition to calcium homeostasis. The present study was planned to Assessment of vitamin D status in healthy volunteers and to correlate levels of vitamin D in different age groups. The study was conducted in the
Department of Biochemistry, M. M. Institute of Medical Sciences and Research, Mullana, Ambala (Haryana). The study population two hundred (200) healthy volunteers were derived from employees and students aged 20-60 years of either sex. The mean vitamin D in age group of 20 -
30 years, 31 - 40 years, 41 - 50 years and 51 - 60 was 28.99 ± 8.40 ng/ml, 33.63 ± 11.37, 29.59 ± 5.93 and 25.80 ± 5.74 respectively which was significantly higher p value (p <0.001). However, there was a positive correlation between age groups (20-30 and 30-40), (20-30 and 50-50), (30-40 and 40-50) and (50-60 and 30-40, 40-50) with significant p value (p < 0.05). Thus, the present study suggests that vitamin D decreases with increasing age. Screening for vitamin D on a regular basis may help to identify a subgroup of peoples with a cluster of proven and modifiable risk
factors that are at high risk for bone diseases; cancer, autoimmune diseases and cardiovascular diseases need more intensive therapy and closer follow up because they could benefit from early intervention and treatment.

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