Enteric coated Pellets of Isoniazid: Method Optimization and evaluation

MONIKA OLA VEENA S BELGAMWAR

Abstract


Present study aims method optimization for fabrication and evaluation of pellets containing isoniazid to deliver in intestine. Enteric coated Isoniazid pellets were fabricated by Extrusion-Spheronization technique & by Fluidized coating too, by using water as a solvent in core as well as in enteric layer formation. The effect of sub coating layer, different polymer and their concentrations were evaluated. In-Vitro release was studied at pH1.2 and 6.8. Flow property, tensile strength, friability and outer surface by using SEM also studied.   The final formulation by both method showed intestinal release upto 12 hrs at pH 6.8 with lesser release profile at pH 1.2. FTIR studies indicate compatibility of all the excipients used in the formulation of pellets.  Sub coating layer helps to reduce the amount of enteric coating layer for the effective intestinal delivery.  Intestine target sustain release pellets were prepared. The percentage cumulative release of pellets found 100.2%. Study of processing method concluded that both the methods are significant but the FBD is economical and less time consuming. The subcoat layer helps to reduce the required amount of enteric coating polymer for efficient intestinal delivery. The pellets can use to enhance the efficiency of first-line therapy of Tuberculosis, also can reduces the occurrence of resistance.


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