A Study of Dyslipidemias in Sub Clinical Hypothyroidism Around Nainital Region

Seema Gupta, Sangeeta Singh, Govind Singh, Narendra Kumar Sah Rajesh Pandey4 and S.K.Aggarawal

Abstract


Subclinical hypothyroidism (SCH) is defined as the presence of elevated thyroid stimulating hormone (TSH) with peripheral thyroid hormone thyroxine (T4) and triiodothyronine (T3) in their reference range. SCH association with dyslipidemia and hence with cardiovascular disease (CVD) is still controversial. The aim of the present case-control study was to analyze the association between different types and degrees of lipid disorders in SCH. In over a period of 3.5 years, 749 subjects were included in the study, out of which 399 were SCH patients and 350 were healthy age and sex matched euthyroid controls. The data of lipid profile parameters (mg/dl) in SCH patients vs. euthyroid controls are as follows: mean serum total cholesterol (TC) levels (188.81±47.19 vs. 138.94±33.68, p<0.0001), low density lipoprotein cholesterol (LDL-C) levels (134.84±48.29 vs.  105.08±28.58, p<0.0001) and triglyceride levels (164.55±88.38 vs. 124.81±51.2, p<0.0001). All the above lipid profile parameters were significantly higher when compared with euthyroid controls. No statistical difference was observed in high density lipoprotein cholesterol (HDL-C) levels in mg/dl (47.68± 6.88 vs. 44.79±8.98, p=0.352). The levels of TC, LDL-C, TG were also found to be increased with increasing grades of SCH (Grade I: TSH: 6.1- 10μIU/ml; Grade II: TSH: 10.1-15 μIU/ml; Grade III: TSH >15μIU/ml). No significant difference was observed in HDL-C levels and TC, HDL-C ratio with rising TSH values. This study concludes that SCH has adverse effects on lipid profile parameters (TC, LDL-C and TG) which may predispose these patients to the development of CVD.


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