Analgesic Activity of Psidium guajava root extracts

Girish Kumar Gupta1, Manisha Bhatia, Randhir Singh

Abstract


Natural products constitute the major division of pharmacotherapy. Psidium guajava Linn. has received much attention due to a variety of potential beneficial effects. Numerous polyphenolic compounds, triterpenoids and other chemical compounds are present in this plant. So the present study was designed to investigate the analgesic activity of petroleum ether extract and chloroform extract of Psidium guajava in rats. In the present study, analgesic activity of petroleum ether extract and chloroform extract of roots of Psidiium guajava L. was evaluated for the first time. Extracts were prepared by cold maceration process. The analgesic
activity was evaluated by using the tail immersion test and
Eddy's hot plate method. Different doses (100, 150 and
200 mg/kg) of petroleum ether extract (PEE) and chloroform extract (CE) of root of Psidiium guajava L were used for the study. Different doses (100, 150 and 200 mg/kg) of PEE of Psidium guajava produced a significant increase in withdrawal time in mice in tail immersion test and effect was found to be dose dependent. Similar results were observed with different doses (100, 150 and 200 mg/kg) of CE of Psidium guajava. The Evaluation of analgesic activity in Eddy's hot plate method revealed that PEE and CE has significant analgesic activity. The
increase in time was found be dose dependent. The results
obtained from the study indicate that PEE and CE of
Psidium guajava have significant analgesic activity.

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